Targeting structural flexibility in HIV-1 protease inhibitor binding
نویسندگان
چکیده
منابع مشابه
Targeting structural flexibility in HIV-1 protease inhibitor binding.
HIV-1 protease remains an important anti-AIDS drug target. Although it has been known that ligand binding induces large conformational changes in the protease, the dynamic aspects of binding have been largely ignored. Several computational models describing protease dynamics have been reported recently. These have reproduced experimental observations, and have also explained how ligands gain ac...
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ژورنال
عنوان ژورنال: Drug Discovery Today
سال: 2007
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2006.12.011